Interrogating circulating immune cell methylome differences across the TB disease spectrum — ASN Events
  1. Schedule
  2. Session 9: Science Bites (Concurrent Session)
  3. Interrogating circulating immune cell methylome differences across the TB disease spectrum

Interrogating circulating immune cell methylome differences across the TB disease spectrum (#304)

David Vincent L Romero 1 2 , Abhimanyu Abhimanyu 3 , Dylan Sheerin 1 2 , Jovana Maksimovic 4 5 , Robert J Wilkinson 3 6 7 , Hanif Esmail 3 8 9 , Belinda Phipson 1 , Quentin Gouil 1 , Matthew E Ritchie 1 , Anna K Coussens 1 2 3
  1. Walter and Eliza Hall Institute for Medical Research, Parkville, VIC, Australia
  2. Department of Medical Biology, University of Melbourne, Melbourne, Vic, Australia
  3. Department of Infectious Diseases, Wellcome Centre for Infectious Diseases Research in Africa, Cape Town, Western Cape, South Africa
  4. Computational Biology Program, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia
  5. Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia
  6. Infectious Diseases, The Francis Crick Institute, London, England
  7. Department of Infectious Diseases, Imperial College London, London, United Kingdom
  8. Medical Research Council Clinical Trials, Univerity College London, London, United Kingdom
  9. WHO Collaborating Centre for Tuberculosis Research and Innovation, Institute for Global Health, London, United Kingdom
Publish consent withheld
  1. Trauer, J.M., et al., Risk of Active Tuberculosis in the Five Years Following Infection . . . 15%? Chest, 2016. 149(2): p. 516-525.
  2. DiNardo, A.R., et al., DNA hypermethylation during tuberculosis dampens host immune responsiveness. J. Clin. Invest., 2020. 130(6): p. 3113-3123.
  3. Chen, Y.C., et al., Aberrant Toll-like receptor 2 promoter methylation in blood cells from patients with pulmonary tuberculosis. J Infect, 2014. 69(6): p. 546-57.